Description
Recombinant full-length human PP2Cg was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_177983.
PP2Cgamma is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PP2C gamma is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome (1). PP2C gamma is highly expressed in testis, skeletal muscle, and heart (2). PP2C gamma also plays a main role in regulating cell cycle progression